I. Raw Materials
1. PEA:
Features five core effects—anti-inflammation, analgesia, skin repair, joint health support, and neuroprotective support.
2. Dendrobium officinale:
Contains NMN ("youth factor") and ASP polysaccharides. It exhibits anti-aging effects (enhances NAD⁺ levels), antidepressant properties (regulates gut microbiota → activates the BDNF-TrkB-CREB signaling pathway), and skin moisturizing benefits.
3. Haematococcus pluvialis:
Boasts high natural astaxanthin content (all-trans isomer >90%), with antioxidant capacity 550 times that of vitamin E and 10 times that of β-carotene. Approved as a novel food ingredient in 2010, it is applied in anti-inflammatory repair, anti-aging, liver protection, cardioprotection, and other fields.
II. Process Technologies
1. Liposomes
Characteristics:
- Intelligent recognition and precision targeting to directly act on lesions;
- Enhanced retention and prolonged circulation for sustained efficacy;
- Bionic design enabling stealth delivery and precise guidance.
Liposomes can improve the targeting of drug delivery, enhance drug affinity with cell membranes, prolong drug action, reduce toxicity, and avoid drug resistance. For traditional Chinese medicine (TCM) liposomes, they can encapsulate water-insoluble TCM active ingredients, as well as many potent TCMs with significant side effects but excellent curative effects—improving efficacy and medication safety. For anticancer drugs, liposomes enable selective killing or inhibition of cancer cells without damaging or inhibiting normal cells. TCM liposome delivery systems include intravenous, oral, and pulmonary administration.
2. Injectable Microsphere Formulations
Core Advantages:
(1) Long-acting sustained release: Significantly extends administration intervals and reduces frequent dosing;
(2) Precision targeting: Drugs directly reach lesions to maximize potency and efficacy;
(3) Stable drug release: Reduces plasma drug concentration fluctuations for sustained and consistent efficacy;
(4) Avoids first-pass metabolism: Improves bioavailability, suitable for patients with oral intolerance;
(5) Safe with low side effects: Controllable local drug concentration minimizes systemic reactions;
(6) Improves compliance: Simplifies administration regimens, suitable for long-term treatment scenarios.
3. Gel Formulations
(1) Precision targeting: Direct delivery to the target site for faster and more focused onset of action;
(2) Long-acting sustained release: Local drug retention without loss, significantly extending administration intervals;
(3) Stable drug release: No fluctuations in plasma drug concentration for sustained and stable efficacy;
(4) Local accumulation: Minimal systemic exposure, ensuring safety, low side effects, and good tolerance;
(5) Convenient administration: Easy and efficient to operate, suitable for multiple clinical scenarios;
(6) Biocompatible: Stable gel system with superior tissue compatibility.
Modified long-acting hydrogel injection for canine osteoarthritis: "Single injection maintains efficacy for 3 months."
4. Transdermal Delivery Technology
- Suspension cream/gel: Drugs are dispersed as 0.1~100μm particles in the matrix, suitable for poorly soluble drugs, with appropriate particle size, uniform distribution, and stable particles;
- Soluble microneedle patch: Dissolves within 10 minutes, preventing drug loss caused by pet licking and reducing administration difficulty for owners.
5. Other Complex Formulations
(1) Nanosuspensions (ophthalmic/injectable): Carrier-free "pure drug" nanoparticles that improve solubility, prolong retention time, and enable sustained release;
(2) Drug-loaded chip technology: Enables timed, targeted, and quantitative drug release, avoids drug-drug interactions, and improves compliance. Pet compound anthelmintic drug-loaded chips achieve "single administration with dual protection" to enhance administration convenience.
III. Ease of Use
1. Precise drug dosage with proven efficacy; scientific formulation of nutritional products with functional properties, adhering to the food-medicine homology principle; pet-safe products that meet the needs of rewards and daily nutrition.
2. Excellent palatability: Pets can take the products voluntarily, turning medication into a "reward" experience.
3. User-friendly and aesthetically designed dosage forms and packaging: Double-layer tubes, press tubes, syringe tubes, screw-cap bottles, breakable cards, flash dissolution tablets, oral dissolving films, and soft chewable tablets.
